Canine infectious respiratory disease (CIRD)
Canine infectious respiratory disease (CIRD), more commonly known as a "kennel cough", is an highly contagious disease that affects the dog's respiratory system. CIRD can occur in dogs just by contact with an infected dog in dog parks, at canine sporting events, dog behavior classes, visit at veterinary hospitals, boarding facilities, or pet daycare centers ….
CIRD is a multifactorial and complex pathology caused by several different viral and bacterial agents but Bordetella bronchiseptica is the most common bacteria involved. Bordetella bronchiseptica is a strict aerobic Gram negative bacterium that colonizes the respiratory tract of mammals.
CyaCani : new parenteral Bordetella bronchiseptica vaccine candidate
CyaCani is a sub-cutaneaous CyaA recombinant vaccine candidate which delivers a Bordetella bronchiseptica specific antigen.
Two years CIRD clinical trials conducted on Beagle puppies infected with Bordetella bronchiseptica and vaccinated with CyaCani have confirmed :
a very strong cellular and humoral targeted immune response measured by titration of specific antibodies (Anti CyaA and Anti antigen) and IFNγ
a significant decrease of CIRD symptoms observed (Dry coughing, lethargy, fever, decrease in appetite, sudden lack of energy...)
No adverse reaction
CyaCani induces a cellular and humoral response of the Th-1 phenotype in all vaccinated animals. This response is detectable and amplified following infection only in vaccinated animals. The immunogenic potency of CyaCani is demonstrated.